Journal ClubImmunology

The Role of L(u)ck in T Cell Triggering

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Sci. Signal.  25 Jan 2011:
Vol. 4, Issue 157, pp. jc2
DOI: 10.1126/scisignal.2001657

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T cells use a highly complex signaling apparatus to discriminate between a diverse array of foreign antigens and a myriad of self molecules. The precise mechanism whereby signals are communicated from the antigen-binding T cell receptor to the intracellular signal transduction machinery remains a source of intense debate. This Journal Club article highlights recent research elucidating the role of the Src family kinase Lck in T cell triggering. Resting T cells contain a newly described form of preactivated Lck that is both necessary and sufficient for T cell activation but remains uncoupled from the T cell receptor in the absence of antigen. This research allows a reappraisal of the mechanisms underlying T cell triggering.

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