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vol. 4 no. 157 ra3
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History:
- Received June 2, 2010
- Accepted January 5, 2011
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Copyright © 2011, American Association for the Advancement of Science
Research ArticleMetabolism
Rho and Rho-Kinase Activity in Adipocytes Contributes to a Vicious Cycle in Obesity That May Involve Mechanical Stretch
- Yoshikazu Hara1,
- Shu Wakino1,*,
- Yoshiyuki Tanabe2,
- Maki Saito2,
- Hirobumi Tokuyama1,
- Naoki Washida1,
- Satoru Tatematsu1,
- Kyoko Yoshioka1,
- Koichiro Homma1,
- Kazuhiro Hasegawa1,
- Hitoshi Minakuchi1,
- Keiko Fujimura1,
- Koji Hosoya1,
- Koichi Hayashi1,
- Koichi Nakayama2, and
- Hiroshi Itoh1
- 1Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan.
- 2Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Iwate Medical University, Iwate 028-3694, Japan.
- ↵*To whom correspondence should be addressed. E-mail: swakino{at}sc.itc.keio.ac.jp
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Sci. Signal. 25 Jan 2011:
Vol. 4, Issue 157, pp. ra3
DOI: 10.1126/scisignal.2001227
Vol. 4, Issue 157, pp. ra3
DOI: 10.1126/scisignal.2001227
Yoshikazu Hara
Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan.
Shu Wakino
Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan.
Yoshiyuki Tanabe
Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Iwate Medical University, Iwate 028-3694, Japan.
Maki Saito
Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Iwate Medical University, Iwate 028-3694, Japan.
Hirobumi Tokuyama
Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan.
Naoki Washida
Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan.
Satoru Tatematsu
Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan.
Kyoko Yoshioka
Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan.
Koichiro Homma
Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan.
Kazuhiro Hasegawa
Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan.
Hitoshi Minakuchi
Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan.
Keiko Fujimura
Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan.
Koji Hosoya
Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan.
Koichi Hayashi
Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan.
Koichi Nakayama
Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Iwate Medical University, Iwate 028-3694, Japan.
Hiroshi Itoh
Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan.
