08 February 2011
Vol 4, Issue 159
  • Contents

    • Research Article

    • Perspectives

    • Editors' Choice

      • Repair and Protect

        By stimulating metabolic flux through the pentose phosphate pathway, ATM promotes the production of nucleotides for DNA repair and limits production of reactive oxygen species.

      • Making It Short and Sweet

        O-linked β-N-acetylglucosamine transferase cleaves HCF-1, as well as glycosylating it, in a process necessary for its functional activation.

      • Oncogenic MyD88

        A gain-of-function mutation in MyD88 promotes survival of a B cell lymphoma through activation of NF-κB and JAK-STAT signaling pathways.

      • USE During Stress

        Stress-induced activation of p38 promotes more efficient processing of USE-containing mRNAs, including that encoding thrombin.

      • Wearing the Same Cap

        Some viruses evade detection by encoding enzymes that modify the structures of their coding RNAs to match those of their hosts.

      • Time for a Pause

        A peptide-mediated translational pause facilitates the unconventional splicing of a messenger RNA on the endoplasmic reticulum.

      • Not So Different After All

        Dissociation of a plant receptor kinase inhibitor from its substrate is mediated by tyrosine phosphorylation.

      • Variation in Transit

        The waveform of an action potential can be physiologically modified while it travels along the axon.

      • A Tale of Two Stomata

        The transition from passive to active metabolic control of stomata and plant water balance occurred about 360 million years ago.

About The Cover

Cover image expansion

Online Cover This week's issue features a Research Article that presents the crystal structure of the Arabidopsis thaliana G protein α subunit, AtGPA1. The solution of this structure and molecular dynamics simulations identified differences between AtGPA1 and mammalian G protein α subunits that account for the ability of AtGPA1 to become activated in the absence of canonical G protein–coupled receptors. The image shows the crystal structure of AtGPA1 (blue) bound to GTP-γS (red) and is based on PDB structure 2XTZ. [Image: Chris Bickel, AAAS]