Variation in Transit

Science Signaling  08 Feb 2011:
Vol. 4, Issue 159, pp. ec43
DOI: 10.1126/scisignal.4159ec43

Modulation of the action potential waveform that enhances synaptic transmission has been reported in central neurons after repetitive stimulation or depolarization of the presynaptic neuron. Sasaki et al. used optically targeted axons to observe that modulation of synaptic transmission in cortical neurons does not exclusively depend on release processes but is also achieved by regulation of presynaptic action potential width. Activation of periaxonal astrocytes broadened action potentials and enhanced synaptic transmission.

T. Sasaki, N. Matsuki, Y. Ikegaya, Action-potential modulation during axonal conduction. Science 331, 599–601 (2011). [Abstract] [Full Text]