Mastering Memory Maintenance

Science Signaling  22 Feb 2011:
Vol. 4, Issue 161, pp. ec58
DOI: 10.1126/scisignal.4161ec58

The mechanisms involved in the formation of enduring memories are still largely unknown. Lesburguères et al. (see the Perspective by Sweatt) investigated the hippocampal-cortical dialogue during memory consolidation. Neurons in the rat orbitofrontal cortex appeared to be “tagged” at the time of initial encoding, even though the initial learning was hippocampal. Inactivating the orbitofrontal cortex at the time of encoding affected late memory while not affecting memory during the period when it was still supported by the hippocampus.

E. Lesburguères, O. L. Gobbo, S. Alaux-Cantin, A. Hambucken, P. Trifilieff, B. Bontempi, Early tagging of cortical networks is required for the formation of enduring associative memory. Science 331, 924–928 (2011). [Abstract] [Full Text]

J. D. Sweatt, Creating stable memories. Science 331, 869–870 (2011). [Abstract] [Full Text]