01 March 2011
Vol 4, Issue 162

About The Cover

Cover image expansion

Online Cover This week's issue features a Research Article describing how adenosine triphosphate (ATP) signaling through purinergic receptors reduces the immunosuppressive effects of regulatory T cells (Tregs). In addition, ATP induced the conversion of Tregs to proinflammatory cells. The image shows a section of mouse colon that exhibits infiltrating inflammatory cells because some of the Tregs in the tissue have been rendered ineffective by ATP. [Image: Michele Proietti, Institute for Research in Biomedicine, Bellinzona, Switzerland]