The Yin and Yang of Signaling in Tregs and TH17 Cells

Sci. Signal., 22 March 2011
Vol. 4, Issue 165, p. mr4
DOI: 10.1126/scisignal.2001709

The Yin and Yang of Signaling in Tregs and TH17 Cells

  1. Fan Pan1,
  2. Huimin Fan2,
  3. Ling Lu3,*,
  4. Zhongmin Liu2,*, and
  5. Shuiping Jiang2,*
  1. 1Immunology and Hematopoiesis Division, Department of Oncology and Medicine, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  2. 2Shanghai East Hospital of Tongji University, Shanghai 200120, China.
  3. 3Department of Liver Transplantation, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
  1. *Corresponding authors. E-mail, shuiping.jiang{at} (S.J.); zhongmin_liu{at} (Z.L.); lvling{at} (L.L.)
A report on the Second International Conference on Regulatory T Cells and TH17 Cells and Clinical Application in Human Diseases: “China Tregs/Th17 2010 Shanghai Conference,” Shanghai, China, 17 to 20 July 2010.


Substantial advances in our understanding of the developmental and functional relationship between regulatory T cells (Tregs) and T helper 17 (TH17) cells and their potential clinical applications have been made. In response to these breakthroughs, the second international conference entitled “China Tregs/Th17 2010 Shanghai Conference,” held in Shanghai, China, was dedicated to this topic. Various types of Tregs and TH17 cells, as well as their relevant cytokines, were discussed. Here, we summarize some of the findings shared at the conference, specifically focusing on the biology of TH17 cells, including interleukin-17 (IL-17)–producing innate cells, Tregs, and the factors that control the critical balance between Tregs and cells of the TH17 lineage.


F. Pan, H. Fan, L. Lu, Z. Liu, and S. Jiang, The Yin and Yang of Signaling in Tregs and TH17 Cells. Sci. Signal. 4, mr4 (2011).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882