FGF19 and Liver Metabolism

Science Signaling  29 Mar 2011:
Vol. 4, Issue 166, pp. ec93
DOI: 10.1126/scisignal.4166ec93

Insulin has been the main hormone described to regulate metabolism in the liver. Kir et al. (see the Perspective by Kim-Muller and Accili) now show that fibroblast growth factor 19 (FGF19) appears to be another important regulator, promoting synthesis of glycogen and proteins. FGF19 is made in the small intestine in response to food intake, which stimulates receptors at the liver to regulate metabolism through a mechanism distinct from that of insulin. Unlike insulin, FGF19 did not promote lipogenesis in the liver. In a mouse model of diabetes, FGF19 promoted glycogen synthesis and could thus provide a target for therapeutic control of insulin resistance.

S. Kir, S. A. Beddow, V. T. Samuel, P. Miller, S. F. Previs, K. Suino-Powell, H. E. Xu, G. I. Shulman, S. A. Kliewer, D. J. Mangelsdorf, FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis. Science 331, 1621–1624 (2011). [Abstract] [Full Text]

J. Y. Kim-Muller, D. Accili, Selective insulin sensitizers. Science 331, 1529–1531 (2011). [Abstract] [Full Text]