Editorial GuideCancer

Focus Issue: Rendering Resistance Futile

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Sci. Signal.  29 Mar 2011:
Vol. 4, Issue 166, pp. eg3
DOI: 10.1126/scisignal.2002014

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In conjunction with the Science special issue on cancer (http://www.sciencemag.org/special/cancer2011/), this issue of Science Signaling focuses on mechanisms whereby cancer cells become resistant to antineoplastic therapy. This issue explores mechanisms whereby cancer cells can become resistant to classical chemotherapy drugs aimed at rapidly proliferating cells or to newer agents that depend on specific inhibition of oncogenic kinases or downstream components of aberrantly activated signaling pathways.

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