Science Signaling Podcast: 29 March 2011

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Sci. Signal.  29 Mar 2011:
Vol. 4, Issue 166, pp. pc6
DOI: 10.1126/scisignal.2001941

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This Podcast features a conversation with the senior author of a Research Article published in the March 29 issue of Science Signaling. Thomas Graeber discusses his group’s phosphoproteomic analysis of a leukemia cell line, which reveals a mechanism by which leukemia cells may become resistant to chemotherapeutic agents that target tyrosine kinases. They found that the sensitivity of leukemias driven by the Bcr-Abl fusion protein to tyrosine kinase inhibitors depends on the cells’ reliance on negative feedback mechanisms that limit the activity of the Src family of tyrosine kinases.

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