Science Signaling Podcast: 26 April 2011

See allHide authors and affiliations

Science Signaling  26 Apr 2011:
Vol. 4, Issue 170, pp. pc8
DOI: 10.1126/scisignal.2002099

You are currently viewing the abstract.

View Full Text


This Podcast features a conversation with the senior author of a Research Report published in the April 22 issue of Science. Chuan-ju Liu discusses his group’s finding that the growth factor progranulin (PGRN) bound to the tumor necrosis factor receptor (TNFR) and antagonized signaling by TNFα. Mice lacking PGRN developed more severe inflammatory arthritis in response to immunization with collagen than normal mice, and PGRN treatment reduced the severity of symptoms in mouse models of rheumatoid arthritis.

View Full Text