PerspectiveCell Biology

PI3K and Chemotaxis: A Priming Issue?

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Sci. Signal.  26 Apr 2011:
Vol. 4, Issue 170, pp. pe22
DOI: 10.1126/scisignal.2002019

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Although the spatiotemporal activation of phosphoinositide 3-kinases (PI3Ks) at the leading edge of chemotaxing cells represents a key marker of polarity, both Dictyostelium discoideum and neutrophils lacking measurable PI3K activity can still migrate directionally under certain conditions. Evidence from various papers suggests that the differentiation state of cells or their priming status can consolidate otherwise contradictory findings.

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