Science Signaling Podcast: 3 May 2011

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Sci. Signal.  03 May 2011:
Vol. 4, Issue 171, pp. pc9
DOI: 10.1126/scisignal.2002075

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This Podcast features a conversation with the senior author of a Research Article published in the May 3 issue of Science Signaling. Thomas Mitchell discusses his group’s identification of the mechanism through which monophosphoryl lipid A (MLA) stimulates the immune system without triggering inflammation. Lipopolysaccharide (LPS) and MLA both bind to and activate Toll-like receptor 4 (TLR4), but only LPS stimulates a toxic inflammatory response. Embry et al. now show that whereas LPS triggers two pathways downstream of TLR4, MLA triggers only one of these and does not lead to activation of the inflammasome.

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