PerspectiveCell Biology

New Roles for Lysosomal Trafficking in Morphogen Gradient Sensing

Science Signaling  03 May 2011:
Vol. 4, Issue 171, pp. pe24
DOI: 10.1126/scisignal.2002053

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Abstract

The way in which cells recognize their position in a gradient of morphogen controls differentiation during embryogenesis. New findings indicate that the rate at which internalized morphogen receptors are trafficked to lysosomes is key to the accurate and precise sensing of morphogen gradients and the appropriate initiation of differentiation programs during development.

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