Science Signaling Podcast: 5 July 2011

Sci. Signal., 5 July 2011
Vol. 4, Issue 180, p. pc13
DOI: 10.1126/scisignal.2002276

Science Signaling Podcast: 5 July 2011

  1. Yuanzheng He1 and
  2. Annalisa M. VanHook2
  1. 1Laboratory of Structural Sciences, Van Andel Research Institute, 333 Bostwick Avenue, NE, Grand Rapids, MI 49503, USA.
  2. 2Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005, USA.

Abstract

This Podcast features a conversation with an author of a Research Article published in the 5 July 2011 issue of Science Signaling. Yuanzheng He discusses his group’s finding that the anti-inflammatory drug chloroquine synergizes with glucocorticoids in treating symptoms of inflammatory arthritis in a mouse model. Chloroquine inhibited the lysosome, which enhanced glucocorticoid signaling by increasing the stability or abundance of the glucocorticoid receptor and other members of the nuclear receptor family. These results suggest that lysosomes are a potential target for treating autoimmune and inflammatory diseases as well as disorders caused by aberrant nuclear receptor signaling.

Citation:

Y. He and A. M. VanHook, Science Signaling Podcast: 5 July 2011. Sci. Signal. 4, pc13 (2011).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882