Editors' ChoiceNeuroscience

Gut Reaction

Science Signaling  20 Sep 2011:
Vol. 4, Issue 191, pp. ec265
DOI: 10.1126/scisignal.4191ec265

Guanylyl cyclase-C (GC-C) is a membrane protein that functions as a receptor for peptide hormones produced in the gut. When stimulated, it produces the signaling second messenger guanosine 3′,5′-monophosphate. Gong et al. report that GC-C also functions in the mouse midbrain. Neurons in this area use the neurotransmitter dopamine, and activation of GC-C caused enhanced responsiveness of neurons to the neurotransmitters glutamate and acetylcholine. Behavioral abnormalities of mice lacking GC-C expression showed some similarity to behaviors observed in humans with attention deficit hyperactivity disorder.

R. Gong, C. Ding, J. Hu, Y. Lu, F. Liu, E. Mann, F. Xu, M. B. Cohen, M. Luo, Role for the membrane receptor guanylyl cyclase-C in attention deficiency and hyperactive behavior. Science 333, 1642–1646 (2011). [Abstract] [Full Text]