Contents
Vol 4, Issue 195
Contents
Research Article
- Agrobacterium Counteracts Host-Induced Degradation of Its Effector F-Box Protein
A plant pathogen prevents degradation of its key virulence factor in infected host cells.
Review
- Structural Basis for Activation and Inhibition of Class I Phosphoinositide 3-Kinases
The regulatory interactions between PI3Ks and their binding partners could be exploited for therapies.
Journal Club
- α-Synuclein Promotes Neuroprotection Through NF-κB–Mediated Transcriptional Regulation of Protein Kinase Cδ
α-Synuclein may protect dopaminergic neurons from apoptosis by reducing the abundance of a kinase involved in cell death.
Editors' Choice
- Two Ways to Breathe Easier Without iNOS
Inducible nitric oxide synthase in distinct cell types contributes to the pathogenesis of chronic obstructive pulmonary disease and pulmonary hypertension.
- Tryptophan Fix
A tumor-derived tryptophan metabolite activates the aryl hydrocarbon receptor in an autocrine and paracrine manner to promote tumor progression.
- How Escherichia coli Got Its Stripes
A synthetic circuit implementing density-controlled bacterial motility autonomously produces a tunable stripe pattern.
- Keep Your Distance
Innate immune signaling and antimicrobial peptide activity maintain separation of the microbiota and intestinal epithelium.
- Mucosal Microbe Melee
Commensal microflora promote the pathogenesis of mucosally acquired viruses.
- Evading Apoptosis to Promote Persistent Infection
By stimulating the production of an alternatively spliced antagonistic form of TRAIL, HIV-infected cells escape apoptotic death.
- Promoting Glucose Homeostasis with an ER Stress Response
Phosphorylation of a transcription factor induced by ER stress by p38 promotes glucose homeostasis.
