Vol 4, Issue 196
- Proteomic and Functional Genomic Landscape of Receptor Tyrosine Kinase and Ras to Extracellular Signal–Regulated Kinase Signaling
Interactome mapping and functional genomics in Drosophila reveal common and specific components of a mitogen-activated protein kinase pathway.
A chemical genetics strategy identified 67 previously unknown substrates of the kinase ERK2, including the transcriptional repressor ETV3.
- Working Without Kinase Activity: Phosphotransfer-Independent Functions of Extracellular Signal–Regulated Kinases
ERK2 plays kinase-independent roles in chromatin remodeling, gene transcription, and cell cycle regulation.