PodcastImmunology

Science Signaling Podcast: 1 November 2011

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Science Signaling  01 Nov 2011:
Vol. 4, Issue 197, pp. pc23
DOI: 10.1126/scisignal.2002614

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Abstract

This Podcast features a conversation with the senior author of a Research Article published in the 1 November 2011 issue of Science Signaling. Xiaoxia Li discusses her group’s identification of a region within the adaptor protein Act1 that is critical for its binding to the proinflammatory Interleukin-17 receptor. They designed a cell-permeable peptide that can bind to the receptor and inhibit its signaling, thus reducing inflammation, in a mouse model. Similar strategies might be successful in developing methods for blocking IL-17-dependent inflammatory disease in humans.

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