PresentationDevelopmental Biology

Direct Delivery Mechanisms of Morphogen Dispersion

Science Signaling  22 Nov 2011:
Vol. 4, Issue 200, pp. pt8
DOI: 10.1126/scisignal.2002434

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A Presentation from the 1st International HEALING Meeting: Hh-Gli Signaling in Development, Regeneration, and Disease, Kolymbari, Crete, 23 to 25 June 2011.

Abstract

This Presentation focuses on how morphogen signaling proteins disperse across developmental fields. Although the steady-state distributions of morphogen signaling proteins have been described well in a number of contexts, the mechanisms that generate these distributions have remained uncertain. Results presented here show that these proteins transfer from producing to target cells at points of direct contact, even when the producing and target cells are not immediate neighbors.

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