Research ArticlePhysiology

i2 Signaling Promotes Skeletal Muscle Hypertrophy, Myoblast Differentiation, and Muscle Regeneration

Sci. Signal.  29 Nov 2011:
Vol. 4, Issue 201, pp. ra80
DOI: 10.1126/scisignal.2002038

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Preventing Muscle Wasting

The wasting of skeletal muscle that accompanies various diseases (such as cancer, AIDS, and COPD) contributes to a poor prognosis. Thus, identifying pathways that promote muscle growth and can counteract muscle wasting can reduce the morbidity and mortality associated with these diseases. Minetti et al. (see also the Perspective by Guttridge) show that signaling through the G protein Gαi2 can increase growth and differentiation of muscle cells, promote regeneration after injury in mice, and counteract atrophy in vitro.