Plant biology

Plant Defenses

Science Signaling  13 Dec 2011:
Vol. 4, Issue 203, pp. ec347
DOI: 10.1126/scisignal.4203ec347

In plants, the R (resistance) proteins represent one arm of the innate defense system against pathogens. Once activated by detection of an invading pathogen’s effector protein, the R proteins promote a cascade of defensive responses that can include cellular suicide (see the Perspective by McDowell). Using the plant Arabidopsis and pathogenic Pseudomonas bacteria, Heidrich et al. found that the plant protein EDS1 (ENHANCED DISEASE SUSCEPTIBILITY1) was important for the nucleocytoplasmic communications required to mediate the transition from threat detection to defense implementation. Bhattacharjee et al. identified interactions between the plant EDS1 and SRFR1 (SUPPRESSOR OF rps4-RLD1) proteins in the microsomal fraction of the cytoplasm, where SRFR1 may serve to tether R proteins and temper their responses to initial pathogen detection.

K. Heidrich, L. Wirthmueller, C. Tasset, C. Pouzet, L. Deslandes, J. E. Parker, Arabidopsis EDS1 connects pathogen effector recognition to cell compartment–specific immune responses. Science 334, 1401–1404 (2011). [Abstract] [Full Text]

S. Bhattacharjee, M. K. Halane, S. H. Kim, W. Gassmann, Pathogen effectors target Arabidopsis EDS1 and alter its interactions with immune regulators. Science 334, 1405–1408 (2011). [Abstract] [Full Text]

J. M. McDowell, Beleaguered immunity. Science 334, 1354–1355 (2011). [Abstract] [Full Text]