PerspectiveStructural Biology

Three-Dimensional Docking in the MAPK p38α

Science Signaling  20 Dec 2011:
Vol. 4, Issue 204, pp. pe47
DOI: 10.1126/scisignal.2002697

You are currently viewing the abstract.

View Full Text

Log in


Abstract

Mitogen-activated protein kinases (MAPKs) are central players in eukaryotic signaling circuitry and interact with numerous other proteins. The structure of a MAPK with a kinase-binding domain (KBD) from a MAPK phosphatase, MKP5, reveals that the contacts with the MAPK are made with the folded three-dimensional KBD, although the KBD occupies the same binding site on the kinase as canonical linear docking motifs found in substrates and MAPK kinases. This structure offers insights into the action of MKP5 and other MKPs.

View Full Text