Focus Issue: Wnt and β-Catenin Signaling in Development and Disease

Sci. Signal., 10 January 2012
Vol. 5, Issue 206, p. eg2
DOI: 10.1126/scisignal.2002806

Focus Issue: Wnt and β-Catenin Signaling in Development and Disease

  1. Nancy R. Gough*
  1. Editor of Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.
  1. * Corresponding author. E-mail, ngough{at}aaas.org.

Abstract

The Wnt pathways represent key signaling networks involved in development, both in tissue specification and in cellular migration. Wnt signaling also plays key roles in tissue homeostasis in adult animals, and aberrant Wnt signaling is associated with several forms of cancer. This issue includes descriptions of a proapoptotic function for Wnt signaling in melanoma, an interplay between Wnt and bone morphogenetic proteins in tooth organogenesis, and a noncanonical role for Wnt in neuronal guidance.

Citation:

N. R. Gough, Focus Issue: Wnt and β-Catenin Signaling in Development and Disease. Sci. Signal. 5, eg2 (2012).

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IOVS 55, 4863-4872 (1 August 2014)

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882