LRRK2 and Human Disease: A Complicated Question or a Question of Complexes?

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Science Signaling  17 Jan 2012:
Vol. 5, Issue 207, pp. pe2
DOI: 10.1126/scisignal.2002680

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Leucine-rich repeat kinase 2 (LRRK2) is linked to various diseases, including Parkinson’s disease, cancer, and leprosy. Data from LRRK2 knockout mice has highlighted a possible role for LRRK2 in regulating signaling pathways that are linked to the pathogenesis of Crohn’s disease. Here, we examine how LRRK2’s role as a signaling hub in the cell could lead to diverse pathologies.

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