PodcastHost-Pathogen Interactions

Science Signaling Podcast: 14 February 2012

Science Signaling  14 Feb 2012:
Vol. 5, Issue 211, pp. pc4
DOI: 10.1126/scisignal.2002905

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This Podcast features a conversation with authors of a Research Article published in the 7 February 2012 issue of Science Signaling. Marc Peters-Golden discusses his group’s finding that infection of alveolar macrophages with the fungus Candida albicans triggered the production of the lipid mediator prostaglandin E2 (PGE2), prevented polymerization of the actin cytoskeleton, and inhibited phagocytosis of the pathogen by the macrophages. Dephosphorylation and activation of the actin depolymerizing factor cofilin-1 was necessary for these inhibitory effects of PGE2 and was mediated by the protein phosphatase activity of PTEN (phosphatase and tensin homolog deleted on chromosome 10). Immunosuppression is associated with increased production of PGE2, which may help to explain how antifungal responses are attenuated in immunocompromised individuals.

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