PerspectivePhosphoinositide Signaling

How Actin Gets the PIP

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Science Signaling  28 Feb 2012:
Vol. 5, Issue 213, pp. pe7
DOI: 10.1126/scisignal.2002839

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Actin polymerization is fundamental to many cellular activities, including motility, cytokinesis, and vesicle traffic. Actin dynamics must be tightly regulated so that cells execute a response appropriate to need, which is achieved through coordination of the functions of a molecular toolkit of proteins and phospholipids. Among the latter, phosphoinositides have a particularly important role, and PI(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) generates distinct phenotypic outcomes such as actin comet formation and membrane ruffling. New evidence reveals that it is not just the production of PI(4,5)P2 that is important in determining outcome, but that changes in the abundance of other phosphoinositides also play a role.

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