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This Podcast features a conversation with authors of a Research Article published in the 6 March 2012 issue of Science Signaling. Joan Brugge and John Albeck discuss their work on a mechanism of crosstalk between growth factor signaling pathways that control proliferation in breast epithelial cells. Insulin-like growth factor 1 (IGF-1) and epidermal growth factor (EGF) both promoted proliferation of breast epithelial cells, but only EGF stimulated proliferation on its own. IGF-1 did not stimulate proliferation on its own, but instead enhanced the proliferative response to EGF. The signaling cascades stimulated by EGF and IGF-1, which are commonly used as indicators of oncogenic signaling, differentially regulated the activity of the cell cycle inhibitor p57. Thus, the status of p57 may indicate which pathway to inhibit in breast cancer.