Research ArticleGPCR SIGNALING

Differential β-Arrestin–Dependent Conformational Signaling and Cellular Responses Revealed by Angiotensin Analogs

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Sci. Signal.  24 Apr 2012:
Vol. 5, Issue 221, pp. ra33
DOI: 10.1126/scisignal.2002522

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Biasing β-Arrestin Responses

Activation of the angiotensin type 1 receptor (AT1R) by different ligands can trigger distinct signaling pathways and cellular responses. One such pathway is mediated by the adaptor protein β-arrestin, which can promote cellular proliferation and migration in response to AT1R activation. Zimmerman et al. found that the ability of angiotensin II analogs to enhance β-arrestin–dependent proliferation or migration was linked to distinct conformational changes in β-arrestin induced by the analogs. Thus, biased signaling downstream of the AT1R exists at the level of β-arrestin. These results may help in developing drugs that target specific signaling events triggered by this receptor without affecting others, thereby causing fewer side effects.