Editors' ChoiceS-Nitrosylation

Handling Nitrosative Stress

Science Signaling  01 May 2012:
Vol. 5, Issue 222, pp. ec125
DOI: 10.1126/scisignal.2003170

S-nitrosylation of proteins is a principal mechanism of cellular signaling in eukaryotes but has not been reported in microbes. The transcription factor OxyR serves to protect bacterial cells from reactive oxygen species produced by cell metabolism in the presence of oxygen. Seth et al. found that when cells grew in the presence of nitrate, OxyR was modified by S-nitrosylation of the same cysteine residue that gets oxidized in cells grown aerobically. However, the nitrosylated OxyR activated a different set of genes, some of which appeared to protect the cell from excessive S-nitrosylation.

D. Seth, A. Hausladen, Y.-J. Wang, J. S. Stamler, Endogenous protein S-nitrosylation in E. coli: Regulation by OxyR. Science 336, 470–473 (2012). [Abstract] [Full Text]

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