Research ArticleCell Biology

Syndecan 4 Regulates FGFR1 Signaling in Endothelial Cells by Directing Macropinocytosis

Science Signaling  08 May 2012:
Vol. 5, Issue 223, pp. ra36
DOI: 10.1126/scisignal.2002495

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Limiting the Signal Through Macropinocytosis

Fibroblast growth factor 2 (FGF2) triggers migration and proliferation of endothelial cells by binding to fibroblast growth factor receptor 1 (FGFR1) and the co-receptor syndecan 4 (S4). Activation of FGFR1 initiates signaling through mitogen-activated protein kinases (MAPKs). Elfenbein et al. found that S4 decreased the internalization of FGFR1 through a process called macropinocytosis. Furthermore, S4-mediated macropinocytosis of FGFR1 decreased the amplitude and increased the deactivation kinetics of MAPK signaling. Thus, these results indicate that S4 controls the duration of MAPK activation in response to binding of FGF2 to FGFR1.