ReviewStructural Biology

Signal Activation and Inactivation by the Gα Helical Domain: A Long-Neglected Partner in G Protein Signaling

Science Signaling  29 May 2012:
Vol. 5, Issue 226, pp. re2
DOI: 10.1126/scisignal.2003013

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  1. Article
    1. Abstract
    2. Introduction
    3. Crystal Structure Data Reveal a Displacement of the G Protein Helical Domain
    4. Experimental Validation of New Structural Models
    5. Posttranslational Modifications That Target the Helical Domain
    6. Contact Sites in the Helical Domain Contribute to Protein-Binding Specificity
    7. Opportunities for New Pharmacology
    8. References and Notes
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