Research ArticleDNA damage

Coupled Activation and Degradation of eEF2K Regulates Protein Synthesis in Response to Genotoxic Stress

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Sci. Signal.  05 Jun 2012:
Vol. 5, Issue 227, pp. ra40
DOI: 10.1126/scisignal.2002718

Article Information

vol. 5 no. 227 ra40

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History: 
  • Received November 22, 2011
  • Accepted May 9, 2012

Author Information

  1. Flore Kruiswijk1,
  2. Laurensia Yuniati1,
  3. Roberto Magliozzi1,
  4. Teck Yew Low2,3,
  5. Ratna Lim1,
  6. Renske Bolder1,
  7. Shabaz Mohammed2,3,
  8. Christopher G. Proud4,
  9. Albert J. R. Heck2,3,
  10. Michele Pagano5,6, and
  11. Daniele Guardavaccaro1,*
  1. 1Hubrecht Institute–KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, Netherlands.
  2. 2Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht, Netherlands.
  3. 3Netherlands Proteomics Center, Padualaan 8, 3584 CH Utrecht, Netherlands.
  4. 4School of Biological Sciences, School of Biological Sciences, Life Sciences Building, University of Southampton, Southampton SO17 1BJ, UK.
  5. 5Department of Pathology, NYU Cancer Institute, New York University School of Medicine, 522 First Avenue, SRB1107, New York, NY 10016, USA.
  6. 6Howard Hughes Medical Institute.
  1. *To whom correspondence should be addressed. E-mail: d.guardavaccaro{at}hubrecht.eu

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