Editors' ChoiceStructural Biology

Plant Hormone Modulators

Sci. Signal.  03 Jul 2012:
Vol. 5, Issue 231, pp. ec182
DOI: 10.1126/scisignal.2003353

The activity and stability of several plant hormones are modulated by conjugation with various amino acids and their derivatives. Westfall et al. solved the crystal structures for two acyl acid amido synthetases from Arabidopsis. The findings suggest how the enzymes might discriminate between apolar and acidic amino acids and lend insight into the reaction chemistries that add functional diversity to hormone signaling pathways.

C. S. Westfall, C. Zubieta, J. Herrmann, U. Kapp, M. H. Nanao, J. M. Jez, Structural basis for prereceptor modulation of plant hormones by GH3 proteins. Science 336, 1708–1711 (2012). [Abstract] [Full Text]