Vol 5, Issue 232
- Differential Regulation by Cyclic Nucleotides of the CNGA4 and CNGB1b Subunits in Olfactory Cyclic Nucleotide–Gated Channels
Different subunits of olfactory CNG channels enable specific regulation of channel activity by cAMP or cGMP.
- Complementary Phosphorylation Sites in the Adaptor Protein SLP-76 Promote Synergistic Activation of Natural Killer Cells
Targeted tyrosine phosphorylation of an adaptor protein is required for the synergistic activation of natural killer cells by distinct pairs of receptors.
- Comment on “A Dynamic Network Model of mTOR Signaling Reveals TSC-Independent mTORC2 Regulation”: Building a Model of the mTOR Signaling Network with a Potentially Faulty Tool
Manning questions whether the biochemical readout used to test the network models is sufficiently specific.
- Response to Comment on “A Dynamic Network Model of mTOR Signaling Reveals TSC-Independent mTORC2 Regulation”: Building a Model of the mTOR Signaling Network with a Potentially Faulty Tool
Dalle Pezze et al. respond to criticisms regarding the specificity of phosphorylation of Ser2481 of mTOR as a specific readout of mTORC2 activity.
Engineering nonimmune cells with components of the T cell receptor signaling system enables the interaction with antigen-presenting cells to initiate T cell receptor activation.