Research ArticleImmunology

The Scaffolding Protein Synapse-Associated Protein 97 Is Required for Enhanced Signaling Through Isotype-Switched IgG Memory B Cell Receptors

Sci. Signal.  31 Jul 2012:
Vol. 5, Issue 235, pp. ra54
DOI: 10.1126/scisignal.2002820

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Boosting Antibody Production

The initial exposure of naïve B cells that have IgM B cell receptors (BCRs) on their surface to a foreign antigen produces a primary antibody response and generates memory B cells that have IgG BCRs, which respond to subsequent encounters with the same antigen by rapidly producing large amounts of antibodies. Liu et al. investigated differences in the signaling capacities of IgG and IgM BCRs and found that the scaffold protein SAP97 bound to IgG, but not IgM, BCRs at the immunological synapse, enabling BCR clustering and enhanced signaling. These findings may provide therapeutic targets to block enhanced BCR activation in autoimmune disease and in some B cell tumors.