Vol 5, Issue 240
- FAM123A Binds to Microtubules and Inhibits the Guanine Nucleotide Exchange Factor ARHGEF2 to Decrease Actomyosin Contractility
Unlike related proteins, FAM123A interacts with microtubule-associated proteins and alters microtubule dynamics.
- Guanylyl Cyclases A and B Are Asymmetric Dimers That Are Allosterically Activated by ATP Binding to the Catalytic Domain
An ATP-binding allosteric site could be pharmacologically targeted to alter the activity of membrane guanylyl cyclases.
Stress induces JNK phosphorylation of a mitochondrial fusion protein, leading to its degradation, mitochondrial fragmentation, and apoptosis.