Research ArticleCell Biology

FAM123A Binds to Microtubules and Inhibits the Guanine Nucleotide Exchange Factor ARHGEF2 to Decrease Actomyosin Contractility

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Sci. Signal.  04 Sep 2012:
Vol. 5, Issue 240, pp. ra64
DOI: 10.1126/scisignal.2002871

Article Information

vol. 5 no. 240 ra64

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History: 
  • Received January 19, 2012
  • Accepted August 13, 2012

Author Information

  1. Priscila F. Siesser1,*,
  2. Marta Motolese2,*,,
  3. Matthew P. Walker1,
  4. Dennis Goldfarb1,3,
  5. Kelly Gewain1,
  6. Feng Yan1,
  7. Rima M. Kulikauskas4,
  8. Andy J. Chien4,
  9. Linda Wordeman5, and
  10. Michael B. Major1,
  1. 1Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Box 7295, Chapel Hill, NC 27599, USA.
  2. 2Howard Hughes Medical Institute, Department of Pharmacology, and Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Box 357370, Seattle, WA 98195, USA.
  3. 3Department of Computer Science, University of North Carolina at Chapel Hill, Box 3175, Chapel Hill, NC 27599, USA.
  4. 4Division of Dermatology, Department of Medicine, University of Washington School of Medicine, Box 358056, 815 Mercer Street, Seattle, WA 98109, USA.
  5. 5Department of Physiology and Biophysics, University of Washington School of Medicine, Box 357370, Seattle, WA 98195, USA.
  1. To whom correspondence should be addressed. E-mail: benmajor{at}med.unc.edu
  • * These authors contributed equally to this work.

  • Present address: Istituto Neurologico Mediterraneo Neuromed, Pozzilli 86077, Italy.

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