ReviewMOLECULAR BIOLOGY

Pseudogenes: Newly Discovered Players in Human Cancer

Sci. Signal.  18 Sep 2012:
Vol. 5, Issue 242, pp. re5
DOI: 10.1126/scisignal.2002858

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Abstract

Because they are generally noncoding and thus considered nonfunctional and unimportant, pseudogenes have long been neglected. Recent advances have established that the DNA of a pseudogene, the RNA transcribed from a pseudogene, or the protein translated from a pseudogene can have multiple, diverse functions and that these functions can affect not only their parental genes but also unrelated genes. Therefore, pseudogenes have emerged as a previously unappreciated class of sophisticated modulators of gene expression, with a multifaceted involvement in the pathogenesis of human cancer.

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