Editors' ChoiceCancer

Keeping Cancer Cells at Bay

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Sci. Signal.  02 Oct 2012:
Vol. 5, Issue 244, pp. ec257
DOI: 10.1126/scisignal.2003658

Cancer cells are often aneuploid; that is, they have an abnormal number of chromosomes. But to what extent this contributes to the tumorigenic phenotype is not clear. Senovilla et al. (see the Perspective by Zanetti and Mahadevan) found that tetraploidization of cancer cells can cause them to become immunogenic and thus aid in their clearance from the body by the immune system. Cells with excess chromosomes put stress on the endoplasmic reticulum, which leads to movement of the protein calreticulin to the cell surface. Calreticulin exposure in turn caused recognition of cancer cells in mice by the host immune system. Thus, the immune system appears to serve a protective role in eliminating hyperploid cells that must be overcome to allow unrestricted growth of cancer cells.

L. Senovilla, I. Vitale, I. Martins, M. Tailler, C. Pailleret, M. Michaud, L. Galluzzi, S. Adjemian, O. Kepp, M. Niso-Santano, S. Shen, G. Mariño, A. Criollo, A. Boilève, B. Job, S. Ladoire, F. Ghiringhelli, A. Sistigu, T. Yamazaki, S. Rello-Varona, C. Locher, V. Poirier-Colame, M. Talbot, A. Valent, F. Berardinelli, A. Antoccia, F. Ciccosanti, G. M. Fimia, M. Piacentini, A. Fueyo, N. L. Messina, M. Li, C. J. Chan, V. Sigl, G. Pourcher, C. Ruckenstuhl, D. Carmona-Gutierrez, V. Lazar, J. M. Penninger, F. Madeo, C. López-Otín, M. J. Smyth, L. Zitvogel, M. Castedo, G. Kroemer, An immunosurveillance mechanism controls cancer cell ploidy. Science 337, 1678–1684 (2012). [Abstract] [Full Text]

M. Zanetti, N. R. Mahadevan, Immune surveillance from chromosomal chaos? Science 337, 1616–1617 (2012). [Abstract] [Full Text]