HCN1 Channels: A New Therapeutic Target for Depressive Disorders?

Sci. Signal., 2 October 2012
Vol. 5, Issue 244, p. pe44
DOI: 10.1126/scisignal.2003593

HCN1 Channels: A New Therapeutic Target for Depressive Disorders?

  1. Mala M. Shah*
  1. UCL School of Pharmacy, University College, London WC1N 1AX, UK.
  1. *Corresponding author. E-mail: mala.shah{at}ucl.ac.uk


The hyperpolarization-activated cyclic nucleotide-gated channels are cation channels that are activated by hyperpolarizing potentials. These channels are concentrated in cortical and hippocampal pyramidal cell dendrites, where they play an important role in determining synaptic input integration and thus neuronal output. These channels have thus been suggested to be involved in physiological processes such as cognition as well as pathophysiological states such as epilepsy. Recent evidence suggests that these channels may also be therapeutic targets for treatment of depressive disorders.


M. M. Shah, HCN1 Channels: A New Therapeutic Target for Depressive Disorders?. Sci. Signal. 5, pe44 (2012).

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