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Online Cover This week features a Research Article that describes how Akt counteracts growth-promoting signals by inhibiting the transcriptional silencer and Polycomb group protein Bmi1, thus leading to the transcription of tumor suppressor genes. The image shows a Polycomb group protein altering chromatin structure. [Image: Yana Hammond/AAAS]

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882