PKR-Dependent Inflammatory Signals

See allHide authors and affiliations

Sci. Signal.  23 Oct 2012:
Vol. 5, Issue 247, pp. pe47
DOI: 10.1126/scisignal.2003511

You are currently viewing the abstract.

View Full Text


Double-stranded RNA–dependent protein kinase (PKR) is implicated in inflammation and immune dysfunction through its regulation of mitogen-activated protein kinases, interferon regulatory factor 3, nuclear factor κB, apoptosis, and autophagy pathways. A study shows that PKR is also required for the activation of inflammasomes and the subsequent release of high-mobility group box 1 (HMGB1) protein, a proinflammatory cytokine. Thus, the cell stress kinase PKR has multifaceted roles in the regulation of inflammatory immune responses, and PKR and HMGB1 are attractive targets for inflammasome-associated diseases.

View Full Text