PerspectiveImmunology

PKR-Dependent Inflammatory Signals

Science Signaling  23 Oct 2012:
Vol. 5, Issue 247, pp. pe47
DOI: 10.1126/scisignal.2003511

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Abstract

Double-stranded RNA–dependent protein kinase (PKR) is implicated in inflammation and immune dysfunction through its regulation of mitogen-activated protein kinases, interferon regulatory factor 3, nuclear factor κB, apoptosis, and autophagy pathways. A study shows that PKR is also required for the activation of inflammasomes and the subsequent release of high-mobility group box 1 (HMGB1) protein, a proinflammatory cytokine. Thus, the cell stress kinase PKR has multifaceted roles in the regulation of inflammatory immune responses, and PKR and HMGB1 are attractive targets for inflammasome-associated diseases.

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