Science Signaling Podcast: 30 October 2012

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Sci. Signal.  30 Oct 2012:
Vol. 5, Issue 248, pp. pc24
DOI: 10.1126/scisignal.2003704

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This Podcast features an interview with Yotis Senis, senior author of a Research Article published in the 30 October 2012 issue of Science Signaling. Senis’s group investigated the role of the inhibitory receptor G6b-B in platelet biology. Platelets are activated to form clots when they bind to components of the extracellular matrix (ECM) that are exposed at sites of blood vessel damage. Platelets are produced by megakaryocytes, which reside in the ECM-rich bone marrow. Despite producing the same repertoire of surface receptors as platelets, megakaryocytes are not activated by binding to ECM. Using a mouse knockout, the authors show that the inhibitory receptor G6b-B is required in megakaryocytes for the production of functional platelets, maintains megakaryoctyes in an inactive state, and keeps circulating platelets inactive until they come into contact with ECM. Mice lacking this receptor exhibited defects in platelet number, size, and function.

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