Research ArticleCancer

Key Roles for the Lipid Signaling Enzyme Phospholipase D1 in the Tumor Microenvironment During Tumor Angiogenesis and Metastasis

Science Signaling  06 Nov 2012:
Vol. 5, Issue 249, pp. ra79
DOI: 10.1126/scisignal.2003257

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Targeting the Tumor Microenvironment

Phospholipase D (PLD) is an enzyme that produces the signaling lipid phosphatidic acid and promotes the proliferation, survival, invasion, and metastasis of cancer cells. Chen et al. examined the role of the PLD isoforms PLD1 and PLD2 in the tumor environment. They found that compared to wild-type mice, mice deficient in PLD1 developed smaller, less vascularized tumors as well as fewer lung metastases in a xenograft model. Furthermore, mice treated with an inhibitor of PLD1 also developed smaller tumors and fewer metastases. These results suggest that PLD1 inhibitors could be developed to treat cancer.