Editors' ChoiceAntiviral Response

Wound Healing and Immunity

Science Signaling  13 Nov 2012:
Vol. 5, Issue 250, pp. ec292
DOI: 10.1126/scisignal.2003766

Although wound healing and infection are often overlapping processes, whether the wound healing response modulates the immune response is not well understood. Doronin et al. (see the Perspective by Herzog and Ostrov) now show that coagulation factor X, an important component of the blood clotting cascade, helps to trigger antiviral immunity in response to adenovirus infection in mice. Factor X binds to human type C adenovirus with very high affinity. Structural analysis identified the critical binding residues between factor X and adenovirus, which, when mutated, inhibited binding. Despite being able to infect splenic macrophages in mice, transcriptional profiling of spleens from mice infected with a mutant adenovirus unable to bind to factor X revealed impaired activation of signaling cascades associated with innate immunity.

K. Doronin, J. W. Flatt, N. C. Di Paolo, R. Khare, O. Kalyuzhniy, M. Acchione, J. P. Sumida, U. Ohto, T. Shimizu, S. Akashi-Takamura, K. Miyake, J. W. MacDonald, T. K. Bammler, R. P. Beyer, F. M. Farin, P. L. Stewart, D. M. Shayakhmetov, Coagulation factor X activates innate immunity to human species C adenovirus. Science 338, 795–798 (2012). [Abstract] [Full Text]

R. W. Herzog, D. A. Ostrov, A decorated virus cannot hide. Science 338, 748–749 (2012). [Abstract] [Full Text]