PerspectiveDevelopmental Biology

Remodeling a Tissue: Subtraction Adds Insight

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Sci. Signal.  27 Nov 2012:
Vol. 5, Issue 252, pp. pe52
DOI: 10.1126/scisignal.2003620

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Sculpting a body plan requires both patterning of gene expression and translating that pattern into morphogenesis. Developmental biologists have made remarkable strides in understanding gene expression patterning, but despite a long history of fascination with the mechanics of morphogenesis, knowledge of how patterned gene expression drives the emergence of even simple shapes and forms has grown at a slower pace. The successful merging of approaches from cell biology, developmental biology, imaging, engineering, and mathematical and computational sciences is now accelerating progress toward a fuller and better integrated understanding of the forces shaping morphogenesis.

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