Editors' ChoiceNeuroscience

The Good Side of Inflammation

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Sci. Signal.  11 Dec 2012:
Vol. 5, Issue 254, pp. ec322
DOI: 10.1126/scisignal.2003856

The zebrafish brain is much more adept than the human brain at recovering after traumatic injury. Kyritsis et al. (see the Perspective by Stella) investigated the cellular events that support regeneration in the zebrafish brain. Although inflammation is part of the response in both settings, the zebrafish brain goes on to initiate proliferation of replacement neurons. By inciting inflammation without neuronal damage, radial glial cells could be pushed into neurogenesis.

N. Kyritsis, C. Kizil, S. Zocher, V. Kroehne, J. Kaslin, D. Freudenreich, A. Iltzsche, M. Brand, Acute inflammation initiates the regenerative response in the adult zebrafish brain. Science 338, 1353–1356 (2012). [Abstract] [Full Text]

N. Stella, Inflammation to rebuild a brain. Science 338, 1303–1304 (2012). [Abstract] [Full Text]