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Online Cover This week features a Research Article that uncovers a second domain in the scaffold KSR1 named CC-SAM that mediates membrane binding. The image shows the NMR solution structure of CC-SAM, highlighting the α helix required for membrane binding. [Image: Dorothy Koveal/Department of Molecular Biology, Cell Biology and Biochemistry, Brown University]

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882